scientific presentations
MGTA-145 Stem Cell Mobilization
Rapid and Robust Mobilization of CD34+ HSCs without G-CSF Following Administration of MGTA-145 Alone or in Combination with Plerixafor
EBMT Annual Meeting Poster, Aug/Sept 2020
MGTA-145, in Combination with Plerixafor, Rapidly Mobilizes Large Numbers of HSCs in Humans That Can Be Gene Edited with CRISPR/Cas9 and Mediate Superior Engraftment to Standard-of-Care (Abstract #123)
ASGCT Annual Meeting Presentation, May 2020
MGTA-145/Plerixafor-Mediated HSC Mobilization Allows for Efficient In Vivo HSC Transduction and Stable Gene Marking in Murine Peripheral Blood Cells (Abstract #810)
ASGCT Annual Meeting Poster, May 2020
Phase 1 Clinical Study of MGTA-145 in Combination with Plerixafor Shows Rapid Single-Day Mobilization and Collection of CD34+ HSCs without G-CSF (Abstract #73)
TCT Annual Meeting Presentation, February 2020
Rapid and Robust Mobilization of CD34 + HSCs without G-CSF Following Administration of MGTA-145 Alone or in Combination with Plerixafor (Abstract #1961)
MGTA-117 (previously CD117-ADC) Conditioning Program
A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates (Abstract #5)
TCT Annual Meeting Presentation, February 2020
A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window Across Species (Abstract #44)
TCT Annual Meeting Presentation, February 2020
A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates (Abstract #610)
CD117-ADC Conditioning Program
A Single Dose Of Short Half-Life Cd117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy In Nonhuman Primates
EBMT Annual Meeting Poster, Aug/Sept 2020
CD45-ADC Conditioning Program
A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Ameliorate Disease in Preclinical Autoimmune Disease Models and Enable autoHSCT
EBMT Annual Meeting Poster, Aug/Sept 2020
A CD45-targeted Antibody Drug Conjugate Enables Allogeneic Hematopoietic Stem Cell Transplantation as a Single Agent in Mice
EBMT Annual Meeting Poster, Aug/Sept 2020
A Novel Targeted Approach to Achieve Immune System Reset: A Single Dose of Magenta CD45-Targeted Antibody Drug Conjugate Enables Autologous HSCT and Ameliorates Disease in Murine Models of Autoimmune Disease (Abstract #3208)
ASH Annual Meeting Poster, December 2019
Administration of a CD45 Antibody Drug Conjugate As a Novel, Targeted Approach to Achieve Immune System Reset: A Single Dose of CD45-targeted ADC Safely Conditions for Autologous Transplant and Ameliorates Disease in Multiple Models of Autoimmune Disease (Abstract #120)
MGTA-456 Cell Therapy
High Dose Stem Cell Therapies, Like MGTA-456, Enable
Complete Neural and Peripheral Disease Cross-Correction Through Rapid and Robust Hematopoietic Engraftment
EBMT Annual Meeting Poster, Aug/Sept 2020
High Dose Hematopoietic Stem Cell Therapies, like MGTA-456, Enable Complete Neural, Peripheral, and Skeletal Disease Cross-Correction Through Rapid and Robust Engraftment (Abstract #248)
ASGCT Annual Meeting Poster, May 2020
MGTA-456 Cell Therapy in Inherited Metabolic Diseases (IMD) Yields Rapid and Durable LongTerm Improvement of Disease-Specific Outcomes in a Phase 2 Trial (Abstract #20)
TCT Annual Meeting Presentation, February 2020
High Dose Hematopoietic Stem Cell Transplantation Leads to Rapid Neural and Peripheral Disease Cross-Correction via Robust Hematopoietic and Microglia Recovery
TCT Annual Meeting Poster, February 2020
MGTA-456, An Aryl Hydrocarbon Receptor Antagonist Based Expansion of CD34+ Hematopoietic Stem Cells, Permits Selection of Better HLA Matched Cord Units and Promotes Faster Neutrophil Recovery and Uniform Engraftment With Potentially Less Acute Graft-vs-Host-Disease (Abstract #804)
ASH Annual Meeting Presentation, December 2019
E478 Stem Cell Gene Therapy Expansion
Expansion with E478 Significantly Increases the Rate of CRISPR-Mediated Homology Directed Repair (HDR) and Improves Engraftment of Human Hematopoietic Stem Cells (Abstract #10)
ASGCT Annual Meeting Presentation, May 2020